Spotlight on Scientific Discoveries 1 (Day 1)

Chaired by Professor Clare Isacke

Professor Clare Isacke, Group Leader

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

Nature Cancer (Mar 2023). Turrell FK, Orha R, Guppy NJ, Gillespie A, Guelbert M, Starling C, Haider S, Isacke CM.

Professor Udai Banerji, Group Leader

A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer

Clinical Cancer Research (Nov 2022). Banerjee S, Michalarea V, Ang JE, Ingles Garces A, Biondo A, Ruddle R, Raynaud F, Riisnaes R, Gurel B, Tunariu N, Prout T, Parmar M, Zachariou A, Turner A, Jenkins B, Minchom A, Lopez J, de Bono J, Hall E, Banerji U.

Dr Anna Kirby, Consultant Clinical Oncologist

Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial

The Lancet (Jun 2023). Haviland JS, Kirby AM, Griffin CL, Sydenham MA, Titley JC, Emson M, Hopwood P, Yarnold JR, Bliss JM.

Dr Matthew Jessop, Postdoctoral Training Fellow

Structural basis of tankyrase activation by polymerization

Nature (Nov 2022). Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S.

Dr Anguraj Sadanandam, Group Leader

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

Nature (May 2023). Poudel P, Regulan C, Ps H, Nyamundanda G, Sadanandam A.