Spotlight on Scientific Discoveries 2 (Day 2)

Chaired by Professor Nick James

Dr Annie Baker, Senior Staff Scientist

Phenotypic plasticity and genetic control in colorectal cancer evolution; The co-evolution of the genome and epigenome in colorectal cancer

Nature (Oct 2022). Househam J, Heide T, Cresswell GD, Spiteri I, Zapata L, Lynn C, James C, Mossner M, Fernandez-Mateos J, Baker A-M, Gabbutt C, Chen B, Lakatos E, Gunasri V, Nichol D, Caravagna G, Chkhaidze K, Sottoriva A, Graham TA.

Dr Zheng Fan, Postdoctoral Training Fellow

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Nature (Mar 2023). Fan Z, Helin K.

Dr Alex Pearson, Senior Scientific Officer

Capivasertib in Hormone Receptor-Positive Advanced Breast Cancer

New England Journal of Medicine (Jun 2023). Turner NC.

Negar Goodarzi, PhD Student

Structural basis of catalytic activation in human splicing

Nature (May 2023). Cretu C, Pena V.

Dr Jadwiga Nieminuszczy, Senior Scientific Officer

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity

Nature Communications (Apr 2023). Broderick R, Nieminuszczy J, Niedzwiedz W.